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New Drug Successful in Treatment of TBIs

Traumatic brain injuries are the leading cause of death and disability among young adults in industrialized countries. It accounts for more potential years of life lost than cancer and cardiovascular decease combined. One of the deadliest consequences of a traumatic brain injury is the swelling of the brain.

As discussed in previous posts, brain cells at the point of impact die, liberating toxic substances that cause the brain to swell and that, at the same time, kill more of the surrounding cells. If doctors fail to stop this deadly vicious circle, the patient dies. Scientists are experimenting with many different drugs and devices to combat this deadly brain swelling. For example, researchers are using a micro computer vacuum pump to drain the deadly toxic substances created by the dead cells. Yet, there has not been much success finding a drug that prevents the cells from dying in the first place. Not until now…

New Drug Shows Promise

Vasopharm GmbH, is a European pharmaceutical company dedicated to the discovery and development of novel therapeutics for the treatment of cerebral and cardiovascular diseases. It recently announced the results of the explorative phase IIa NOSTRA trial of its VAS203 drug in Traumatic Brain Injury. The trial included the use of “in vivo” microdialysis that allowed scientists to monitor the drugs pharmaco-dynamic and pharmaco-kinetic properties, i.e., the effectiveness of the drug as an allosteric nitric oxide NO-synthase antagonist that interrupts the inducible nitric oxide process that causes the brain to swell.

VAS203 did not have any negative effect on the brain’s perfusion pressure, good safety and tolerability and no deaths among the patients to whom it was administered, versus a 12.5 percent mortality rate among those in the control group, who only got a placebo. It is very important to note that the Therapy Intensity Level (TIL), which is a marker evaluating concomitant therapy and intervention by the physicians as a measure for control of intracranial pressure (ICP), showed a substantial reduction among the patients treated with VAS203 when compared to those who received a placebo. Additionally, an extended Glasgow Outcome Scale (eGOS) was used off protocol to assess the level of achieved neurological recovery six months after the injury. When compared to the group on a placebo, patients on VAS203 showed a great increase of their eGOS six months after suffering their injury, which demonstrates a substantially improved recovery.

Expensive Treatments

Given the complexity of these injuries, pharmaceutical companies invest large sums of money trying to discover effective drugs and treatments. Consequently, these drugs and treatments are not cheap. If the traumatic brain injury occurred in an accident for which someone else was responsible, maybe the lawyers of Greenberg, Stone & Urbano, can help. They have the experience necessary to help the victims of traumatic brain injuries caused by someone else’s negligent actions recover money to help pay for their treatment, including rehabilitation therapy, for their daily expenses, for their pain and suffering and for their lost wages.

The Lawyers of Greenberg Stone and Urbano Can Help

With over 75 years of combined experience, the lawyers at Greenberg Stone and Urbano can help victims that have suffered any kind of traumatic brain injury as a result of an accident recover the funds they need for their rehabilitation. These funds may include money for the expensive treatments mentioned in these posts, for rehabilitation therapy, for your pain and suffering and for lost wages.

If you or a loved one have suffered a traumatic brain injury as a result of a car accident, a truck accident, an amusement park accident or as a result of any other kind of accident, you should immediately contact a law firm experienced in handling these cases. Throughout the years, the Miami Dade County Traumatic Brain Injury Law Offices of Greenberg Stone and Urbano have represented many clients that have suffered traumatic brain injuries.

Visit our website to learn more about our firm and contact us today for a free consultation.

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