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New Drug Prevents Secondary Damage to Brain After TBI

According to, a team from the University of Pittsburg School of Medicine has successfully used a new drug called XJB-5-131 to prevent the oxidation of cardiolipin, an important component of the mitochondrial membrane. This membrane is where most of a cell’s supply of chemical energy is generated. Additionally, mitochondria are involved in many other processes, like cellular signaling, cellular differentiation, cell death, control of the cell cycle and cell growth.

The study’s senior author, Hülya Bayιr, M.D., Associate Professor of the Department of Critical Care Medicine at the University of Pittsburgh School of Medicine, explained that her team conducted a global assessment of all the phospholipids in rat brain cells. This revealed that damage from TBI was nonrandom and mostly involved cardiolipin, a phospholipid that is found in the membranes that form mitochondria. A traumatic brain injury causes the oxidation of Cardiolipin, impairing the vital mitochondria membrane.

Cellular Signaling and Traumatic Brain Injuries

One of the functions an impaired mitochondria cannot perform is cellular signaling, which is a system of communication between cells that allows for the coordination of cell actions. By being able to perceive and correctly respond to their microenvironment, a mammal’s embryonic stem cells are able to develop into more specialized kind of cells through another process called cellular differentiation. This process is the basis of the stem cell research currently conducted by scientists trying to regenerate tissue damaged by trauma.

As stated before, the team developed XJB-5-131, a drug that can cross the blood-brain barrier and prevent cardiolipin from oxidation. They took lab rats with an established research model of severe traumatic brain injury and treated some of the injured animals with XJB-5-131 and others with a placebo. In the following weeks the animals treated with the drug performed normal in tests of balance, agility, motor coordination, learning and object recognition, while the animals treated with a placebo showed significant impairment. This result showed that blocking cardiolipin oxidation by XJB-5-131 protected the brain from cell death.

Dr. Bayir explained that “the primary head injury might not be that serious, but that initial injury can set into motion secondary cellular and molecular events that cause more damage to the brain and that ultimately determine the outcome for the patient.”

The Lawyers of Greenberg Stone and Urbano Can Help

With over 75 years of combined experience, the lawyers at Greenberg Stone and Urbano can help victims that have suffered any kind of traumatic brain injury as a result of an accident recover the funds they need for their rehabilitation. These funds may include money for the expensive treatments mentioned in these posts, for rehabilitation therapy, for your pain and suffering and for lost wages.

If you or a loved one have suffered a traumatic brain injury as a result of a car accident, a truck accident, an amusement park accident or as a result of any other kind of accident, you should immediately contact a law firm experienced in handling these cases. Throughout the years, the Miami Dade County Traumatic Brain Injury Law Offices of Greenberg Stone and Urbano have represented many clients that have suffered traumatic brain injuries.

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